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Systematic elucidation of matrix effects in liquid chromatography hyphenated to mass spectrometry

Summary Signal suppression occurs more frequently and more severely than signal enhancement. Injection volume and gradient runtime affect the degree of matrix effects. Stationary phase and pH influence the retention. The organic solvent can be used to control both degree and distribution of matrix within the chromatogram.
Category 2. Symbiosis Application Notes
These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
Matrix plasma
Market Clinical
Compounds Acetamiprid, Thiacloprid, Clothianidin Imidacloprid
Compound Group
Contact Andreas Bruchmann C. vom Eyser, C. Portner, T. Teutenberg, J. Tuerk
Account Axel Semrau GmbH & Co.KG, Stefansbecke 42, 45549 Sprockhövel, Germany, Institut für Energie- und Umwelttechnik e. V., IUTA (Institute of Energy and Environmental Technology), Bliersheimer Str. 58-60, 47229 Duisburg, Germany
Date 4-8-2015
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