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Title	Systematic elucidation of matrix effects in liquid chromatography hyphenated to mass spectrometry
Summary	Signal suppression occurs more frequently and more severely than signal enhancement. Injection volume and gradient runtime affect the degree of matrix effects. Stationary phase and pH influence the retention. The organic solvent can be used to control both degree and distribution of matrix within the chromatogram.
Category	2. Symbiosis Application Notes These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
Matrix	plasma
Market	Clinical
Cartridge
Detection
Compounds	Acetamiprid, Thiacloprid, Clothianidin Imidacloprid
Compound Group
Sample_volume
Contact	Andreas Bruchmann C. vom Eyser, C. Portner, T. Teutenberg, J. Tuerk
Account	Axel Semrau GmbH & Co.KG, Stefansbecke 42, 45549 Sprockhövel, Germany, Institut für Energie- und Umwelttechnik e. V., IUTA (Institute of Energy and Environmental Technology), Bliersheimer Str. 58-60, 47229 Duisburg, Germany
Published
Date	4-8-2015
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