Detailed information
Title	etermination of Tobacco Specific Nitrosamines in Tobacco by on-line spe.
Summary	The first set-up with only a mixed mode cation exchange cartridge or only a polymer reversed phase sorbent showed a huge matrix effect and a large amount of impurities. Using the 2D spe option mXLC provided a very clean extract with good recoveries and no back pressure increase on the LC column. Due to the limit time and more complex method development process, it was not possible to create more data. The calibration curves show a reliable method with good linearity.
Category	2. Symbiosis Application Notes These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
Matrix	Tobacco
Market	Food
Cartridge	PRS cation exchange cartridge and HySphere GP.
Detection
Compounds	N-Nitrosonornicotine (NNN) N-Nitrosoanatabine (NNT) N-Nitrosoanabasine (NNB) 4-methyl-N-nitrosamine-1-(3-pyridyl)-1-Butanone (NNK)
Compound Group	Nitrosamines
Sample_volume	100 µL
Contact	Spark Holland
Account	Spark Holland
Published	yes
Date	4-8-2015
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