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Title	Quantitative androgen profile in plasma using online SPE in combination with UPLC tandem mass spectrometry
Summary	We have developed a sensitive and selective mass spectrometric analysis for the measurement of progestagens and androgens in plasma, which can be completely automated. The assay requires a small volume (method can be scaled down further). Method is sensitive enough to detect DHT in adult males and females routinely. Reference range studies will be started, when the method is completely validated.
Category	2. Symbiosis Application Notes These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
Matrix	Plasma
Market	OSM Clinical
Cartridge	Xbridge C8 cartridges
Detection	XEVO TQ-S, Waters
Compounds	Androstenedione, Testosterone, 17a-Hydroxyprogesterone, Dehydroepiandrosterone , Dihydrotestosterone, Progesterone
Compound Group	progestagen, androgen, steroids
Sample_volume	200 µL
Contact	H.J.R. van Faassen, M.S. Pratt, I.P. Kema
Account	University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands
Published	poster
Date	4-8-2015
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