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Title

Quantitative androgen profile in plasma using online SPE in combination with UPLC tandem mass spectrometry

Summary We have developed a sensitive and selective mass spectrometric analysis for the measurement of progestagens and androgens in plasma, which can be completely automated. The assay requires a small volume (method can be scaled down further). Method is sensitive enough to detect DHT in adult males and females routinely. Reference range studies will be started, when the method is completely validated.
Category 2. Symbiosis Application Notes
These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
 
Matrix Plasma
Market OSM Clinical
Cartridge Xbridge C8 cartridges
Detection XEVO TQ-S, Waters
Compounds Androstenedione, Testosterone, 17a-Hydroxyprogesterone, Dehydroepiandrosterone , Dihydrotestosterone, Progesterone
Compound Group progestagen, androgen, steroids
Sample_volume 200 ÁL
 
Contact H.J.R. van Faassen, M.S. Pratt, I.P. Kema
Account University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands
Published poster
Date 4-8-2015
  Read PDF document
 
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