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USE of online SPE for Clinical research in the automated analysis of Mycophenolic Acid by LC-MS

Summary in this work, an automated LC-MS clinical research method has been developed for the measurement of MPA from plasma. The method utilizes LC-MS equipped with an online SPE system. This combinaiton of SPE sample preparation coupled with the analytical power of LC-MS can prove a very analytically sensitive and efficient method for the analysis of this important immunosuppresant
Category 2. Symbiosis Application Notes
These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
Matrix plasma
Market OSM Clinical
Cartridge Waters Xbridge C18 OSM solid Phase Extraction cartridge
Detection Waters XEVO TQD
Compounds Mycophenolic Acid, MPA
Compound Group Mycophenolic Acid, immunosuppressants
Sample_volume 50ÁL
Contact Martin Eastwood and Lisa Carlton
Account Waters Corporation, Milford, MA, USA
Published poster, Technical Brief
Date 4-8-2015
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Status published