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Simultaneous, Sensitive LC/MS Analysis of Plasma Metanephrines

Summary in this study, a clinical research method has been developed for the simultaneous measurement of three plasma biogenic amines. The method utilizes LC/MS and an online SPE system. This combination of SPE sample preparation coupled with the analyticla power of LC/MS is able to deliver an efficient assay for these important metanephrines
Category 2. Symbiosis Application Notes
These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
Matrix Plasma
Market OSM Clinical
Cartridge Waters MassTrak WCX OSM cartridge
Detection Waters XEVO TQ-S
Compounds Metanephrine, normetanephrine and 3-methoxytyramine, 3-MT
Compound Group Metanephrines
Contact Jeanne Adaway and Brian Keevil
Account University Hospital South Manchester, UK
Published Poster, Technical Brief
Date 4-8-2015
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Status published