Detailed information | |
Title |
Rapid identification of drugs and medications in meconium by XLC-QqTOF |
Summary | Pregnant woman with a history of drug abuse often deny or report only minimally the true extent of their drug exposure. The rapid analysis of a broad-spectrum of drugs in neonatal meconium (fig.1) - a complex, heterogeneous composition consisting of e.g. water, epithelial cells, bile acids, enzymes, sugars, lipids and proteins [1] - has a significant impact on the prompt diagnosis (e.g. neonatal abstinence syndrome - NAS) and to facilitate treatments. Our aim was to develop a rapid drug screening method for the identification of toxicologically relevant substances in human meconium based on automated on-line extraction, HPLC, QQTOF and software assisted library search (XLC-QQTOF). Meconium specimens (n=35) were sent from delivery hospitals from infants of mothers who were suspected (or to be known) to be drug consumers and analyzed via XLC-QQTOF. |
Category | 2. Symbiosis Application Notes These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated |
Matrix | meconium |
Market | Clinical |
Cartridge | Waters WCX Cartridge |
Detection | Triple TOF 5600 (AB Sciex) |
Compounds | Lidocaine (11), paracetamol (8), norfentanyl (6), metoclopramide (5), O-desmethyl-/ tramadol (4/4), hydrocortisone (3), ranitidine (3), ampicilline (2), bupivacaine (2), lopinavir (2), nordazepam/oxazepam, temazepam (2/1/1), quetiapine/N-desalkyl-/7-OH-, (2/2/2), antipyrine (1), atazanavir (1), chlorprotixene (1), haloperidol (1), nalbuphine (1) nor-/ olanzapine(1/1) and phenobarbital (1). |
Compound Group | Drugs of Abuse, Drugs |
Sample_volume | 1 mL |
Contact | Thomas Grobosch, Robert Richter, Torsten Binscheck-Domass |
Account | Labor Berlin - Charité Vivantes GmbH, Laboratory Medicine and Toxicology, Sylter Str. 2, 13353 Berlin, Germany. |
Published | published |
Date | 4-8-2015 |
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Remarks | |
Users | |
Status | poster |